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Miyazaki, T.; Tokimura, F.; Tanaka, S. A review of denosumab for the treatment of osteoporosis. Patient Prefer. Adherence 2014, 8, 463–471. [ Google Scholar] [ CrossRef][ Green Version] Braun, A.C.; Gutmann, M.; Ebert, R.; Jakob, F.; Gieseler, H.; Lühmann, T.; Meinel, L. Matrix Metalloproteinase Responsive Delivery of Myostatin Inhibitors. Pharm. Res. 2017, 34, 58–72. [ Google Scholar] [ CrossRef] Aileen Wuornos was a serial killer. She shot several men in the head and torso, stole their money, and disposed of their bodies carelessly.
Ebner, D.C.; Bialek, P.; El-Kattan, A.F.; Ambler, C.M.; Tu, M. Strategies for skeletal muscle targeting in drug discovery. Curr. Pharm. Des. 2015, 21, 1327–1336. [ Google Scholar] [ CrossRef] When Wuornos was convicted for these multiple murders and sentenced to death, she canceled all appeals. In an interview with a local news station, she proclaimed, “I need to die for the killing of those people.” 94 She continued, “I killed those men, robbed them cold as ice. And I’d do it again . . . I’m the one who hates human life and I’d kill again.” 95 At the time, some people within the criminal justice system, the public, and the media argued that Wuornos might not have been competent for execution. The Miami Herald’s Fred Grimm, for example, emphasized that her behavior was erratic and bizarre. Observers pointed to the fact that she fired her lawyer and instead appointed an evangelical horse trainer who claimed half the rights to movies about her life – actions that hardly demonstrate sound judgment. Many people felt she should have had additional psychiatric examinations.According to the National Library of Medicine of the National Institute of Health ( https://pubmed.ncbi.nlm.nih.gov/12762075/) :
Arthur, J. S. et al. Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins. J. Neurosci. 24, 4324–4332 (2004). Writer Kenneth Turan 100 added a liner note to Wuornos’ story. The Hollywood movie about her life, Monster, won numerous, prestigious awards for acting and writing. Yet no one talked about Wuornos’ story during any award acceptance speeches. “Admittedly,” Turan wrote, “Wuornos is a tough person to thank.” However, he added, not mentioning Aileen Wuornos perpetuated the way she had been marginalized and made invisible through her struggle – a facet of her developmental history that culminated in her terrible crimes. I agree with Turan. If someone had noticed and intervened on her behalf during her tumultuous upbringings, and if her grandmother had let her get the mental health counseling she needed, maybe her life would have taken a different turn. Perhaps there would have been no string of murders along the Florida highway system. Wuornos was, from childhood, abandoned, exposed to trauma, and raped to pregnancy. She had to learn to live in the woods and on the streets. She learned violence as a coping skill. of all outpatient visits are for MSKs = 558 million per year = 1.1 billion hours away from work ( S. Bureau of Labor Statistics (BLS)) Bain, J. et al. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 408, 297–315 (2007). Comparative characterization of newly identified RSK inhibitors first described in references 106–108.When Wuornos was 20 years old, she moved to Florida and met a man named Lewis Gratz Fell, whom she married in May 1976. Fell, whose age was around 70 at the time, had the marriage annulled two months later, 86 claiming that Wuornos was violent with him and squandered his money. Wuornos herself stated that he beat her with his cane. 87 Snedeker, J.G.; Foolen, J. Tendon injury and repair—A perspective on the basic mechanisms of tendon disease and future clinical therapy. Acta Biomater. 2017, 63, 18–36. [ Google Scholar] [ CrossRef] [ PubMed]
Wang, C. Efficacy and Safety of Zoledronic Acid for Treatment of Postmenopausal Osteoporosis: A Meta-Analysis of Randomized Controlled Trials. Am. J. Ther. 2017, 24, e544–e552. [ Google Scholar] [ CrossRef] [ PubMed] Schouten, G. J. et al. IκB α is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J. 16, 3133–3144 (1997). All other MSK programs that I know of are reactive in nature. When an individual is feeling pain or has had an obvious injury like a sprain, strain, slip/fall, etc. than the program starts to resolve the symptoms they are experiencing. This is usually focused on pain; however, can also include limitations in range of motion (mobility) and a reduction in strength. Those are the direct symptoms of an MSK and there are many more indirect symptoms that include depression, anxiety, fear, and of course a loss of productivity (presenteeism and absenteeism). That is why we use what we affectionately refer to as the “blood test” of mobility health with our patented Computer-Aided MSK Assessment (CAMA) system. This system is marker-less (meaning there are no sensors to attach to your body) and takes less than ten minutes to produce a mountain of OBJECTIVE data on your employee’s mobility health by looking at every joint in every motion they perform and analyzing their dynamic posture (as opposed to static posture when not moving) throughout. The system analyzes the range of motion health of each joint based on what the American Academy of Orthopedic Surgeons (AAOS) has determined as ideal based on age, weight, height, and gender. Range of motion limitations are the first indicator of an issue that will produce pain. Our brains are wired to protect our joints from further insult to tissues and injury and the first defense mechanism is to limit your ability to move or use that joint. These limitations might be slight and have been something that came on slowly and worsened over a long period of time making us unaware of the limitation. Smith, J. A. et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer research 65, 1027–1034 (2005). t of employers ranked musculoskeletal issues (MSKs) as the top condition impacting their costs while 85% ranked it among the top three conditions ( National Business Group on Health)Authorities say that during her nursing training, Toppan experimented with the effects of morphine (an opiate narcotic depressant) and atropine (a stimulant at low doses and a depressant at high doses) 46 on her patients. This caused cycles of unconsciousness and alertness until they died. At the time, however, doctors dismissed the deaths of elderly patients as a product of heart disease, stroke, or even diabetes. Later, Toppan told authorities that she got a thrill from the killing. “No voice has as much melody in it as the one crying for life,” she said, “no eyes as bright as those about to become fixed and glassy; no face so beautiful as the one pulseless and cold.” 47 MSKs are responsible for 360 million lost workdays, or 2.9 per employee, annually in the U.S. ( S. Occupational Safety and Health Administration (OSHA)) Carpal Tunnel Syndrome (CTS) is the second most common surgery in the U.S. and accounts for 30 lost days of work on average for every case ( S. Bureau of Labor Statistics (BLS)) Berns, K. et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431–437 (2004). Years later, a relative stated that, despite being a good student and doing well in school, Wuornos started acting out around age ten or eleven. She shoplifted and set a fire that burned her face. 84 When school officials recommended counseling for Wuornos, her grandmother declined to grant permission. When Wuornos got pregnant at age 14, she was sent to live at a home for unwed mothers. Staff reported her as hostile and unable to get along with others. She gave birth to a baby boy, whom she gave up for adoption.
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